Why VRAYLAR?
Is VRAYLAR right for you?
VRAYLAR works to help control the mood swings of bipolar I disorder in adults. Some medicines only treat the highs or lows. But VRAYLAR treats depressive, acute manic, and mixed episodes of bipolar I in adults.
Studies have shown VRAYLAR can:
Improve overall depressive and manic symptoms†‡
Treat mixed episodes (symptoms of depression and mania at the same time)†
Reduce the overall severity of the condition. This was observed in three 3-week mania studies§
†VRAYLAR was not studied to measure symptoms individually.
‡At 3 weeks in 3 manic/mixed episode studies; at 6 weeks in 3 bipolar I depression studies.
§Based on a specific research tool used by healthcare providers.
How does VRAYLAR work?
VRAYLAR is a once-daily capsule that provides full-spectrum relief for all bipolar I disorder symptoms: bipolar I depression, acute mixed episodes and acute mania. While the exact way that VRAYLAR works is unknown, healthcare providers and scientists believe that VRAYLAR helps regulate dopamine and serotonin in the brain.
Watch the video to learn more about how VRAYLAR is thought to work.
Who is VRAYLAR for?
VRAYLAR is approved in adults to treat bipolar I depression and for the short-term treatment of manic or mixed episodes that happen with bipolar I disorder. While anyone can develop bipolar I disorder, it often starts in the late teen or early adult years and lasts a lifetime.
Bipolar I quiz
Answer some questions that could help your healthcare provider determine whether you may have bipolar I disorder.
Bipolar I stories of strength
Every bipolar I disorder journey is different. Watch real stories of real people with bipolar I disorder sharing their personal experiences.
Individual results may vary. Talk to your healthcare provider to see if VRAYLAR may be right for you.
What are the most common side effects of VRAYLAR?
In clinical trials, the most common side effects were difficulty moving or slow movements, tremors, uncontrolled body movements, restlessness and feeling like you need to move around, sleepiness, nausea, vomiting, and indigestion.
Patients taking VRAYLAR experienced changes in blood sugar levels and cholesterol levels similar to those who took placebo. In 6-week and 8-week bipolar I depression studies, patients who took VRAYLAR experienced an average weight gain of 1.2 pounds, compared to those on placebo who lost 0.2 pounds. In 3-week bipolar I mania studies, patients who took VRAYLAR experienced an average weight gain of 1.1 pounds, compared to those on placebo who gained 0.4 pounds.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all possible side effects of VRAYLAR.
Will VRAYLAR cause weight gain?
Most people taking VRAYLAR saw no substantial impact on weight¶
In VRAYLAR clinical trials, weight change reported was ≤1.5 lb.
Weight gain may occur. You and your doctor should monitor your weight regularly.
Average weight change in 6- and 8-week bipolar I depression studies:
Average weight change in 3-week bipolar I mania studies:
¶In clinical studies, 99% of patients in 3-week bipolar mania trials and 97% of patients in 6- and 8-week bipolar depression trials saw no substantial impact on weight (defined as ≥7% change).
Can I anticipate any sexual side effects when using VRAYLAR?
In bipolar I depression clinical studies, less than 1% of patients taking VRAYLAR reported sexual side effects.
Most common sexual adverse reactions across clinical studies#
| Placebo (n=468) |
VRAYLAR 1.5 mg/day (n=470) |
VRAYLAR 3 mg/day (n=469) |
|
|---|---|---|---|
| Abnormal orgasm | 0% | 0% | 0.4% |
| Decreased sex drive | 0% | 0.2% | 0% |
| Erectile dysfunction | 0% | 0.6% | 0.9% |
| Delayed ejaculation | 0% | 0% | 0% |
#These adverse events were self-reported by patients.
Additional resources
Tips for managing bipolar I
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